About the i-CLASSi Tool

Disclaimer: This tool is developed for research and educational purposes only. It is not intended for clinical diagnosis or treatment guidance.

Overview

The InterLymph Consortium, or formally the International Consortium of Investigators Working on Epidemiologic Studies of Lymphoid Malignancies, is an open scientific forum for epidemiologic research in lymphoid malignancies. Formed in 2001, the Consortium is a group of international investigators who have completed or ongoing case-control studies or contribute resources from completed or ongoing cohorts. InterLymph member investigators discuss and undertake research projects that pool data across studies or otherwise undertake collaborative research.

Learn more at the InterLymph website.

Pathology Working Group

The InterLymph Pathology Working Group includes hematopathologists, epidemiologists, computational biologists and researchers committed to harmonizing lymphoid malignancies classification for epidemiologic studies.

Citation

1. Turner, J. J., et al. (2010). InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future directions. Blood, 116(20), e90–e98.
2. Morton, L. M., et al. (2007). Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of InterLymph. Blood, 110(2), 695–708.
3. Pathology Working Group (2025). InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO-HAEM5. Unpublished.

Data Sources

• ICD-O-3 – International Classification of Diseases for Oncology, 3rd Edition (WHO)
• ICD-9 – International Classification of Diseases, Ninth Revision (WHO/CDC)
• ICD-10 – International Classification of Diseases, Tenth Revision (WHO)
• ICD-10-CM – ICD-10 Clinical Modification (U.S. National Center for Health Statistics, CDC)
• ICD-11 – International Classification of Diseases, Eleventh Revision (WHO)
• SNOMED CT – Systematized Nomenclature of Medicine Clinical Terms (© IHTSDO)
• NCIt – NCI Thesaurus, National Cancer Institute
• EFO – Experimental Factor Ontology (EMBL-EBI, licensed under CC BY 4.0)
• UMLS CUI – Unified Medical Language System, Concept Unique Identifiers (U.S. National Library of Medicine)

Copyright and Licensing

This tool integrates content from multiple biomedical classification and ontology systems. All data remain the intellectual property of their respective organizations:

• © World Health Organization (WHO): ICD-O-3, ICD-9, ICD-10, ICD-11.
• © U.S. Centers for Disease Control and Prevention (CDC): ICD-10-CM.
• © International Health Terminology Standards Development Organisation (IHTSDO): SNOMED CT.
• © National Cancer Institute: NCI Thesaurus.
• © U.S. National Library of Medicine: UMLS.
• © EMBL-EBI: EFO (licensed under CC BY 4.0).

All content is used under fair use and for research/educational purposes only. This tool is not intended for clinical decision-making.

Team and Contributors

Webtool Development

• Murat Güler (Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany, murat.guler@dkfz.de)
• Federico Canzian (Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany)

Classification Contributors

1. Alyssa Clay-Gilmour (Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA)
2. Murat Güler (Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany)
3. James R. Cerhan (Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA)
4. Karin E. Smedby (Dept of Medicine Solna, Division of Clinical Epidemiology, Karolinska Institutet, and Dept of Hematology, Karolinska University Hospital, Stockholm, Sweden)
5. Arjan Diepstra (Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands)
6. InterLymph Consortium Pathology and Survival Working Group

Updates

• 10/01/2024 – InterLymph 2025 based on WHO-HAEM5
• 06/22/2010 – InterLymph 2010 based on WHO-HAEM3
• 05/15/2008 – Initial 2008 InterLymph classification